Pharmaceutical tablet disintegration is a critical process for dissolving and enabling the absorption of the drug substance into the blood stream. Authors may use MDPI'sĮnglish editing service prior to publication or during author revisions. Submitted papers should be well formatted and use good English. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Please visit the Instructions for Authors page before submitting a manuscript. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. All manuscripts are thoroughly refereed through a single-blind peer-review process. Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website. Research articles, review articles as well as short communications are invited. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. All submissions that pass pre-check are peer-reviewed. Manuscripts can be submitted until the deadline. Once you are registered, click here to go to the submission form. Manuscripts should be submitted online at by registering and logging in to this website. Of particular interest are studies which investigate the complex interactions of materials, formulations, manufacturing, storage and the disintegration and dissolution performance, and also those with proposed mechanistic models to explain and predict drug release phenomena. In this special issue, contributions are invited which further the understanding, prediction and measurement of disintegration and dissolution of solid oral dosage forms. There is increasing opportunity to design formulations and manufacturing methods to achieve desired release profiles, however the mechanisms behind dosage form disintegration and dissolution are complex and their link to raw material attributes, formulations, manufacturing and storage conditions are not fully understood. granules and spherical agglomerates) and final product microstructures is improving, and with it the ability to control disintegration and dissolution performance. As available manufacturing methods for medicines diversify the level of control over intermediate (e.g. It shows that Eurosceptic dissatisfaction mainly induces partial exits within the EU due to the EU's weak lock-in power, its problematic voice structuring and the lack of proper full exit options.The disintegration and dissolution behaviour of solid oral dosage forms (tablets, capsules and dispersions) is an essential performance measure for all medicines. A theoretical framework on polity formation developed by Bartolini is the most promising basis from which to examine European disintegration as it avoids the problems just mentioned. Yet others fail to interconnect coherently the manifold disintegrative factors. Other theories are too narrowly focused to explain the complex process of disintegration. Some of these theories suffer from a state bias. Theories about European integration, but also international politics, comparative federalism, optimum currency areas and imperial decline appear to be problematic bases to this end. This article looks for a proper theoretical starting point to conceptualize and explain European disintegration. While the possibility of European disintegration is prominently on the public agenda, European Union (EU) studies have so far largely neglected the issue.
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